The lab publishes across stem cells, cardiac cell manufacturing, organoids, translational validation, biomaterials, and regenerative medicine.
Selected published articles.
2026
Scalable differentiation of human cardiac organoids from iPSCs generates cardiac tissues for cardiac cell therapy
Theranostics · Hamad S, Aksoy E, Kalil M, Martínez-Falguera D, Jüngst C, Zahn K, Gaedke F, Peinkofer G, Boukens BJ, Firuzi R, Prause R, Aranyó J, Bisbal F, Iborra-Egea O, Jorge E, Iraola-Picornell G, Teis A, de Raffele M, Delgado V, Nitsche F, Sachinidis A, Khalil M, Alhashimi F, Schauss A, Bayes-Genis A, Gálvez-Montón C, Pfannkuche KP. · DOI
Article
2025
Mass Production of Uniform Embryoid Bodies by Acoustic Standing Waves
Small Methods · Hahn J, Aksoy E, Hamad S, Kuckelkorn C, Gómez Montoya A, Ritter M, Pfannkuche K, Fischer H. · DOI
Article
2025
Cell-Based Therapies: Ferromagnetic Versus Superparamagnetic Cell Targeting
Bioengineering (Basel) · Halhouli T, Münchhalfen L, Hamad S, Schmitz-Ullrich L, Nitsche F, Gaedke F, Schauss A, Zhang L, Pham QK, Bao G, Pfannkuche KP. · DOI
Article
2025
Engineered In Vitro Multi-Cell Type Ventricle Model Generates Long-Term Pulsatile Flow and Modulates Cardiac Output in Response to Cardioactive Drugs
Advanced Healthcare Materials · Kuckelkorn C, Aksoy E, Stojanovic N, Oulahyane L, Ritter M, Pfannkuche K, Fischer H. · DOI
Article
2022
High-efficient serum-free differentiation of endothelial cells from human iPS cells
Stem Cell Research & Therapy · Hamad S, Derichsweiler D, Gaspar JA, Brockmeier K, Hescheler J, Sachinidis A, Pfannkuche KP. · DOI
Article
2022
Engineering of cardiac microtissues by microfluidic cell encapsulation in thermoshrinking non-crosslinked PNIPAAm gels
Biofabrication · Jahn P, Karger RK, Soso Khalaf S, Hamad S, Peinkofer G, Sahito RGA, Pieroth S, Nitsche F, Lu J, Derichsweiler D, Brockmeier K, Hescheler J, M Schmidt A, Pfannkuche K. · DOI
Article
2019
Generation of human induced pluripotent stem cell-derived cardiomyocytes in 2D monolayer and scalable 3D suspension bioreactor cultures with reduced batch-to-batch variations
Theranostics · Hamad S, Derichsweiler D, Papadopoulos S, Nguemo F, Šarić T, Sachinidis A, Brockmeier K, Hescheler J, Boukens BJ, Pfannkuche K. · DOI
Article
2019
In Vitro Grown Micro-Tissues for Cardiac Cell Replacement Therapy in Vivo
Cellular Physiology and Biochemistry · Sahito RGA, Sheng X, Maass M, Mikhael N, Hamad S, Heras-Bautista CO, Derichsweiler D, Spitkovsky D, Suhr F, Khalil M, Brockmeier K, Halbach M, Saric T, Hescheler J, Krausgrill B, Pfannkuche K. · DOI
Acta Biomaterialia · Heras-Bautista CO, Mikhael N, Lam J, Shinde V, Katsen-Globa A, Dieluweit S, Molcanyi M, Uvarov V, Jütten P, Sahito RGA, Mederos-Henry F, Piechot A, Brockmeier K, Hescheler J, Sachinidis A, Pfannkuche K. · DOI
Article
2014
The influence of physiological matrix conditions on permanent culture of induced pluripotent stem cell-derived cardiomyocytes
Biomaterials · Heras-Bautista CO, Katsen-Globa A, Schloerer NE, Dieluweit S, Abd El Aziz OM, Peinkofer G, Attia WA, Khalil M, Brockmeier K, Hescheler J, Pfannkuche K. · DOI
Article
2014
Mesenchymal stem cells and their conditioned medium improve integration of purified induced pluripotent stem cell-derived cardiomyocyte clusters into myocardial tissue
Stem Cells and Development · Rubach M, Adelmann R, Haustein M, Drey F, Pfannkuche K, Xiao B, Koester A, Udink ten Cate FE, Choi YH, Neef K, Fatima A, Hannes T, Pillekamp F, Hescheler J, Šarić T, Brockmeier K, Khalil M. · DOI
Article
2011
Fibroblasts support functional integration of purified embryonic stem cell-derived cardiomyocytes into avital myocardial tissue
Stem Cells and Development · Xi J, Khalil M, Spitkovsky D, Hannes T, Pfannkuche K, Bloch W, Sarić T, Brockmeier K, Hescheler J, Pillekamp F. · DOI
Article
2009
Cardiac myocytes derived from murine reprogrammed fibroblasts: intact hormonal regulation, cardiac ion channel expression and development of contractility
Cellular Physiology and Biochemistry · Pfannkuche K, Liang H, Hannes T, Xi J, Fatima A, Nguemo F, Matzkies M, Wernig M, Jaenisch R, Pillekamp F, Halbach M, Schunkert H, Sarić T, Hescheler J, Reppel M. · DOI
Article
2007
Electrophysiological maturation and integration of murine fetal cardiomyocytes after transplantation
Circulation Research · Halbach M, Pfannkuche K, Pillekamp F, Ziomka A, Hannes T, Reppel M, Hescheler J, Müller-Ehmsen J. · DOI
Article
2002
Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: a tool for efficient genetic engineering of mammalian genomes
Proceedings of the National Academy of Sciences USA · Peitz M, Pfannkuche K, Rajewsky K, Edenhofer F. · DOI
